海角黑料

School of Pharmacy

Image of Siu Yee New

Siu Yee New

BSc Pharmaceutical and Health Sciences Programme Director, Associate Professor,

Contact

  • workRoom B1A05 B1-block
    Malaysia Campus
    Jalan Broga
    43500 Semenyih
    Selangor Darul Ehsan
    Malaysia
  • work+6 (03) 8924 8762

Biography

Dr New Siu Yee received her BSc from University of Technology Malaysia (UTM) and her PhD from National University of Singapore (NUS). During her PhD study, she was involved in multidisciplinary fields of study with three different research groups and spent a year attachment at University of Illinois at Urbana-Champaign (UIUC). After graduated, Dr New worked as Scientist I in Institute Materials Research and Engineering (IMRE), A*Star, Singapore, before joining the 海角黑料 Malaysia. Her current research interest focuses on nanotechnology based biosensors.

Personal research webpage:

Expertise Summary

  • Crystallization techniques for both small molecules and proteins.
  • Various characterization techniques: UV-vis, FTIR, 1D and 2D NMR, electron paramagnetic resonance (EPR), powder X-ray Diffraction (XRD), electrospray ionization-mass spectroscopy (ESI-MS), circular dichroism (CD), spectrofluorometer, surface plasmon resonance (SPR-Biacore), quartz crystal microbalance (QCM), dynamic light scattering (DLS), cyclic voltammetry (CV), thermal gravimetric analysis (TGA), etc.
  • Experience in polymerase chain reaction (PCR), protein expression and purification (fast protein liquid chromatography-FPLC),
  • Experience in handling Schlenk line, TLC, column chromatography, Soxhlet extraction and vacuum liquid chromatography (VLC).
  • Experience in simple modeling using Visual Molecular Dynamic (VMD).

Teaching Summary

MPharm Year 1:

  • Essential Skills of Pharmacists (PHAR1010)

MPharm Year 2 - Year Head:

  • Gastrointestinal & Liver Disorder (PHAR2016) - Module convenor
  • Cardiovascular (PHAR2018)
  • Sexual Health and Pregnancy (PHAR2020)
  • Renal and Endocrine Diseases (PHAR2019)

MPharm Year 3 Research Project - Module convenor

PHS Year 3:

  • Medicinal Chemistry & Drug Design (PHAR3014)

PHS Year 2:

  • Pharmaceutical Analysis & Spectroscopy (PHAR2010)
  • Concepts in Medicinal Chemistry & Drug Discovery (PHAR2014) - Module convenor

PHS Year 1:

  • Laboratories Studies Pharmaceutical Science (PHAR1022)
  • Pharmaceutical & Biological Chemistry 1 (PHAR1008)

Research Summary

Principal Investigator/ Main Applicant (UNM)

2019 - 2021: Facile and PCR-Free Detection of miRNA Using Magnetic Separation and Fluorescent Silver Nanoclusters (Fundamental Research Grant Scheme (FRGS), Ministry of Education (MOE))

2018: SERS Analysis on Reverse Aggregation Control of Cysteamine Coated Gold Nanoparticles (Royal Society of Chemistry; Mobility Grant)

2015 - 2017: Novel Colorimetric & Fluorogenic Nanobiosensors for Telomerase Activity Detection (FRGS, MOE)

2014 - 2015: Systematic Preparation of New Fluorogenic Silver Nanoclusters for Sensing Application (UNMC pump-priming project)

Collaborator

2021 - 2023: Synthesis of protein gold nanoclusters for delivery of silencing-RNA as synergistic colorectal cancer therapy and in situ bioimaging (FRGS, MOE)

2020 - 2021: Colourimetric Nanosensor for the Detection of Ovarian Cancer Biomarker miRNA-665 (MAKNA Cancer Research Award 2020)

2019 - 2020: Detection of Breast Cancer Biomarker miRNA-155 Using Hybridisation Chain Reaction and Silver Nanoclusters (Taylor's University Emerging Research Grant)

2017 - 2019: Elucidation graphene antimicrobial properties against intracellular Staphyloccoccus aureus from bovine mastitis (FRGS, MOE)

2016 - 2019: Development of Multimode "Turn-On" Protein-Gold Nanoclusters for Targeted Theranostics and Imaging of Colon Cancer and Its Metastases (FRGS, MOE)

Selected Publications

  • NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
  • NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
  • STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
  • KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Journal of Biosensors & Bioelectronics. 4(4),

Past Research

Co-Principal Investigator (IMRE, Singapore)

2012 - 2013: Development of biogenic fluorescent metal nanoclusters for biosensing and clinical diagnosis (IMRE core funded project)

Scientist I (IMRE, Singapore)

2012 - 2013: Integrative analysis of the ongogenic transcription factors, AP-2纬 and FoxA1 in breast cancer using nanobiotechnology and genome biology (A*Star JCO funded project)

2011 - 2012: Heterogeneous phase displacement immunoassays for urinary protein markers (Industrial project: IMRE - Nitto Denko Asia Technical Centre Pte. Ltd)

PhD (NUS, Singapore)

2007 - 2011: Supramolecular chemistry and crystal engineering of amino acid Schiff bases

2009 - 2010: Study the effect of site-directed mutagenesis on copper metalloprotein and protein crystallization (University of Illinois, Urbana-Champaign, USA)

Future Research

Please visit our group webpage:

  • WONG, ZHENG WEI and NEW, SIU YEE, 2023. An enzyme-free turn-on fluorescent strategy for nucleic acid detection based on hybridization chain reaction and transferable silver nanoclusters MICROCHIMICA ACTA. 190(1),
  • OOI, JESSICA SUI YING and NEW, SIU YEE, 2022. CHEMISTRYSELECT. 7(7),
  • ZHENG WEI WONG, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED and SIU YEE NEW, 2022. Biosensors and Bioelectronics: X. 12, 100244
  • XIN YI WONG, DANIEL QUESADA-GONZ脕LEZ, SIVAKUMAR MANICKAM, SIU YEE NEW, KASTURI MUTHOOSAMY and ARBEN MERKO脟I, 2021. Scientific Reports. 11, 2375
  • WONG, ZHENG WEI, NG, JECK FEI and NEW, SIU YEE, 2021. Chemistry 鈥 An Asian Journal. 16(24), 4081-4086
  • WAI, JING LUEN and NEW, SIU YEE, 2020. RSC ADVANCES. 10(2), 1088-1094
  • SHI TING LEE, RUMAN RAHMAN, KASTURI MUTHOOSAMY, NUR ALIANA HIDAYAH MOHAMED, XIAODI SU and SAAD TAYYAB, 2019. Microchimica Acta. 186, 81
  • LEE SHI TING, DAVID P BEAUMONT, KASTURI MUTHOOSAMY, SU XIAO DI and NEW SIU YEE, 2018. Analytica Chimica Acta. 1010, 62-68 (IF = 4.95)
  • JIAMIAO HU, SI KEE TAN, MICHELLE GEK LIANG LIM, SHIE HONG CHANG, GUIMEI CUI, SHANSHAN LIU, KAMESH NARASIMHAN, SIU YEE NEW, XUECONG WANG, CONGLING CHEN, HARAPRIYA CHAKRAVARTY, PRASANNA R KOLATKAR, KIN YIP TAM, QIAN LU, XIAODI SU, RALF JAUCH and EDWIN CHEUNG, 2018. Biochemical Journal. 475(11), 1965-1977
  • LEE SHI TING and NEW SIU YEE, 2017. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
  • WAI JING LUEN and NEW SIU YEE, 2017. Gold Nanoparticles-based Colorimetric Aptasensor for Biomarker Detection In: Second International Conference on Molecular Diagnostics and Biomarker Discovery Conference, Penang, Malaysia.
  • NEW SIU YEE and LEE SHI TING, 2017. Formulation of DNA Chimera Templates for Silver Nanoclusters (Invited) In: 25th PolyChar, PWTC, Kuala Lumpur, Malaysia..
  • HOSSEINZADEH PARISA, MARSHALL NICHOLAS M., CHAC脫N KELLY N., YU YANG, NILGES MARK J., NEW SIU YEE, TASHKOV STOYAN A., BLACKBURN NINIAN J. and LU YI, 2016. Proceedings of the National Academy of Sciences of USA. (IF = 鈥9.674)
  • NEW SIU YEE*, LEE SHI TING and SU XIAO DI, 2016. Nanoscale. 8, 17729鈥17746 (IF = 7.76)
  • LEE SHI TING, DAVID BEAUMENT and NEW SIU YEE, 2016. In-Depth Investigation on DNA-AgNCs Designs for Adenosine Detection In: ICONAN, Paris, France.
  • NEW SIU YEE and LEE SHI TING, 2016. Formulation of DNA-Templated Silver Nanoclusters: Location of Nucleation Sequence Matters In: Nano2016, Quebec, Canada.
  • NEW SIU YEE, KHIN MOH MOH AUNG, YONG YU, XIE JIAN PING, LU YI, TAN YEN NEE, CHEUNG EDWIN and SU XIAO DI, 2015. Gold Nanosensors for Protein-Ligand Interactions In: IUPAC 2015, Busan, Korea.
  • YU YONG, NEW SIU YEE, LIN JIAXIAN, SU XIAO DI and TAN YEN NEE, 2015. Journal of Visualized Experiments. e53261 (IF = 1.325)
  • KHIN MOH MOH AUNG, SIU YEE NEW, SHUZHEN HONG, LAURA SUTARLIE, MICHELLE GEK LIANG LIM, SI KEE TAN, EDWIN CHEUNG and XIAODI SU, 2014. Analytical Biochemistry. 448, 95-104 (IF= 2.31)
  • NEW, SIU YEE, AUNG, KHIN MOH MOH, LIM, GEK LIANG, HONG, SHUZHEN, TAN, SI KEE, LU, YI, CHEUNG, EDWIN and SU, XIAODI, 2014. Analytical Chemistry. 86(5), 2361-2370 (IF= 5.83)
  • YU, YONG, NEW, SIU YEE (CONTRIBUTE EQUALLY), XIE, JIANPING, SU, XIAODI and TAN, YEN NEE, 2014. Chemical Communications. (IF= 6.72)
  • STEVEN LUKMAN, NEW SIU YEE and CHEUNG EDWIN, 2014. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (USA Patent) 14/275,526 05/12/2014 00:00:00
  • NEW, SIU YEE, 2014. The 鈥楻evival鈥 of Nanosensors Austin Journal of Biosensors & Bioelectronics (Editorial). 1(1), 1
  • NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Method to screen small ligands and determine protein-ligand interactions (Singapore Patent) 201303835-1 05/16/2013 00:00:00
  • NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Protein-Based Fluorescent Metal Nanoclusters for Drug Screening (Singapore Patent) 201306645-1 09/01/2013 00:00:00
  • STEVEN LUKMAN, NEW SIU YEE, CHEUNG EDWIN and SU XIAO DI, 2013. A Hybrid Sensor using Metal Nanoparticles and Conjugated Polymers (Singapore Patent) 201303638-9 05/10/2013 00:00:00
  • KE LIN, LIM WAI KWAN, NEW SIU YEE, SU XIAO DI and LIU BIN, 2013. Journal of Biosensors & Bioelectronics. 4(4),
  • NEW SIU YEE, SU XIAO DI and TAN YEN NEE, 2013. Bovine Serum Albumin Based Gold Nanocluster for Ligand Sensing In: SNIC-RSC Joint Symposium on Inorganic Chemistry, IMRE, Singapore.
  • NEW, SIU YEE, MARSHALL, NICHOLAS M., HOR, T. S. ANDY, XUE, FENG and LU, YI, 2012. CHEMICAL COMMUNICATIONS. 48(35), 4217-4219 (IF= 6.72)
  • NEW SIU YEE, KHIN MOH MOH AUNG, TAN SI KEE, HONG SU ZHEN, CHEUNG EDWIN and SU XIAO DI, 2012. Gold Nanorods and Nanoparticles Derived Bioassays for Transcription Factors (AP-2纬 and FoxA1)-DNA Binding Detection In: XI International Conference on Nanostructured Materials, Nano2012, Rhodes, Greece.
  • NEW, SIU YEE, THIO, YUDE, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. CRYSTENGCOMM. 13(6), 2114-2122 (IF= 3.86)
  • NEW, SIU YEE, WU, XUAN, BAI, SHI-QIANG, KOH, LIP LIN, HOR, T. S. ANDY and XUE, FENG, 2011. CRYSTENGCOMM. 13(12), 4228-4235 (IF= 3.86)
  • NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Inorganic Chemistry Conference (IC08), University of Canterbury Christchurch, New Zealand.
  • NEW SIU YEE, ANDY HOR TZI SUM and XUE FENG, 2008. Supramolecular Assembly Using Amino Acid Based Schiff Bases In: Singapore-Hong Kong Bilateral Graduate Student Congress, NUS, Singapore.

School of Pharmacy

海角黑料
University Park
Nottingham, NG7 2RD

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