海角黑料

School of Pharmacy

Image of Kuan Hon Lim

Kuan Hon Lim

Deputy Head of School of Pharmacy, Professor,

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Teaching Summary

Involved in the teaching of organic chemistry, analytical chemistry and medicinal chemistry to MPharm and Pharmaceutical and Health Sciences (BSc) students:

PHAR1008 - Pharmaceutical and Biological Chemistry

PHAR1011 - Dyspepsia

PHAR1022 - Laboratory Studies in Pharmaceutical Sciences 1

PHAR1025 - The Fundamentals of Pharmacy

PHAR2010 - Pharmaceutical Analysis and Spectroscopy (Module Leader)

PHAR2012 - Laboratory Studies in Pharmaceutical Sciences 2

PHAR2014 - Concepts in Medicinal Chemistry and Drug Discovery

PHAR2017 - Asthma, Allergies and Immune Diseases (Module Leader for UNM)

PHAR2021 - Pain

PHAR3014 - Medicinal Chemistry and Drug Design

Research Summary

Natural Products Chemistry

In our laboratory, we explore the flora of Malaysia for novel drug leads: isolation and structure determination of natural products possessing significant potential for application as therapeutic agents. We also pursue the total synthesis or semisynthesis of biologically active natural products. We carry out structural modification of natural products to understand the relationships between the molecular structure and its biological activity. We study natural products and novel structures for application in treatment of cancers, hypertension, and other disease-states. The major class of natural products that we are studying are alkaloids.

Selected Publications

  • RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Investigational new drugs. 32(5), 838-50
  • KAM, TOH-SEOK and LIM, KUAN-HON, 2008. Alkaloids of Kopsia. In: CORDELL, G. A., ed., The Alkaloids: Chemistry and Biology 66. Academic Press: The Netherlands. 1-111
  • LIM, K.H., ETOH, T., HAYASHI, M., LIM, K.H. and KAM, T.S., 2009. Tetrahedron Letters. 50, 752-754
  • LIM, K.H., HIRAKU, O., KOMIYAMA, K. and KAM, T.S., 2008. Journal of Natural Products. 71, 1591-1594
  • KAYATRI GOVINDARAJU, YIN YING MAK, FONG KAI LEE, CLAUDIA C. BAUER, KUAN HON LIM, ROBIN S. BON, CIN KONG, SUE-MIAN THEN and KANG NEE TING, 2024. Phytochemistry Letters. 59, 24-35
  • ABUZAID, HANEEN, ABDELRAZIG, SALAH, FERREIRA, LENNY, COLLINS, HILARY M., KIM, DONG-HYUN, LIM, KUAN-HON, KAM, TOH-SEOK, THOMAS, NEIL R., TURYANSKA, LYUDMILA and BRADSHAW, TRACEY D., 2024. ACS Omega. 9(1), 2012-2012
  • TAN Y.-S., NG M.-P., TAN C.H., TANG W.K., SIM K.S., YONG K.T., KRISHNAN P., LIM K.H., LIM S.H. and LOW Y.Y., 2024. Journal of Natural Products. 87, 286-296
  • LIM K.H., MAI C.W., WONG S.K., LOW Y.Y., LIM S.H. and KRISHNAN P., 2024. Phytochemistry Letters. 61, 97-103
  • LI YIN PANG, SUE-MIAN THEN, KUAN HON LIM, KANG NEE TING and SHIN-YEE FUNG, 2023. Biopharmaceutical Potential of Ophiocordyceps sinensis for Human Health. In: DINESH CHANDRA AGRAWAL and MURALIKRISHNAN DHANASEKARAN, eds., Mushrooms with Therapeutic Potentials. Springer. 189鈥�219
  • TANG, S.-Y., TAN, C.-H., SIM, K.-S., YONG, K.-T., LIM, K.H., LOW, Y.-Y. and LIM, S.-H., 2023. Phytochemistry. 208, 113587
  • TAN, Y.-S., WONG, S.-K., YONG, K.-T., LIM, K.H., LIM, S.-H. and LOW, Y.-Y., 2023. Journal of Natural Products. 86, 232鈥�236
  • TAN S.Y., NG M.-P., TAN C.H., SIM K.S., LIM K.H., YONG K.T., LOW Y.Y. and LIM S.H., 2023. Tetrahedron. 149, 133706
  • CHU J.N., KRISHNAN P. and LIM K.H., 2023. Natural Products and Bioprospecting. 13, 53
  • YIN-YING MAK, BI-JUIN LOONG, PAUL MILLNS, CLAUDIA C. BAUER, ROBIN S. BON, YVONNE MBAKI, FONG-KAI LEE, KUAN-HON LIM, CIN KONG and SUE-MIAN THEN, 2022. Phytotherapy Research. 1-12
  • PANG, LI-YIN, LEE, MEI-KEE, KONG, BOON HONG, FUNG, SHIN-YEE, NG, SZU TING, TAN, CHON SENG, THEN, SUE-MIAN, LIM, KUAN-HON, ROBERTS, RICHARD and TING, KANG-NEE, 2022. INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS. 24(3), 1-14
  • CHO, EUN-SEON, KRISHNAN, PREMANAND, LOH, HWEI-SAN, DALY, JANET M., LEONG, CHEE-ONN, MAI, CHUN-WAI, LOW, YUN-YEE, YONG, KIEN-THAI and LIM, KUAN-HON, 2022. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpus petiolatus PHYTOCHEMISTRY. 193,
  • ABUZAID, H., ABDELRAZIG, S., FERREIRA, L., COLLINS, H. M., KIM, D.-H., LIM, K. H., KAM, T.-S., TURYANSKA, L. and BRADSHAW, T. D., 2022. ACS Omega.
  • PAN YAN, UNG YEE TZE, PREMIKA A/P R JAGADISH, LIM KUAN HON, LAMIA NOUSHIN SADEQUE CHOWDHURY, SHANG TAO and ONG CHIN ENG, 2022. Drug Metabolism Letter. 15, 178 - 191
  • LEE, FONG-KAI, KRISHNAN, PREMANAND, MUHAMAD, AZIRA, LOW, YUN-YEE, KAM, TOH-SEOK, TING, KANG-NEE and LIM, KUAN-HON, 2021. NATURAL PRODUCT RESEARCH.
  • CHAN, ZI-YANG, KRISHNAN, PREMANAND, MODARESI, SAYED MOHAMMADHOSSEIN, HII, LING-WEI, MAI, CHUN-WAI, LIM, WEI-MENG, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, YONG, KIEN-THAI, LEONG, ALYSSA ZI-XIN, LEE, MEI-KEE, TING, KANG-NEE and LIM, KUAN-HON, 2021. JOURNAL OF NATURAL PRODUCTS. 84(8), 2272-2281
  • CHAN, ZI-YANG, KRISHNAN, PREMANAND, HII, LING -WEI, MAI, CHUN-WAI, LEONG, CHEE-ONN, LOW, YUN-YEE, WONG, SOON-KIT, TING, KANG-NEE, YONG, KIEN -THAI and LIM, KUAN-HON, 2021. Unusual diarylheptanoid-phenylpropanoid adducts and diarylheptanoid alkaloids from Pellacalyx saccardianus PHYTOCHEMISTRY LETTERS. 46, 36-44
  • KRISHNAN, PREMANAND, LEE, FONG-KAI, YAP, VERONICA ALICIA, LOW, YUN-YEE, KAM, TOH-SEOK, YONG, KIEN-THAI, TING, KANG-NEE and LIM, KUAN-HON, 2020. Journal of natural products. 83(1), 152-158
  • YAP, JING Y, HII, CHING L, ONG, SZE P, LIM, KUAN H, ABAS, FARIDAH and PIN, KAR Y, 2020. Journal of the Science of Food and Agriculture. 100(7), 2932-2937
  • YEAP, JOANNE SOON-YEE, TAN, CHUN-HOE, YONG, KIEN-THAI, LIM, KUAN-HON, LIM, SIEW-HUAH, LOW, YUN-YEE and KAM, TOH-SEOK, 2020. PHYTOCHEMISTRY. 176,
  • ALHUTHALI, HAYAA MOEED, BRADSHAW, TRACEY D., LIM, KUAN-HON, KAM, TOH-SEOK and SEEDHOUSE, CLAIRE H., 2020. BMC CANCER. 20(1),
  • PANG, L.Y., TAN, C.S., NG, S.T., LIM, K.H., THEN, S.M. and TING, K.N., 2020. Life Sciences, Medicine and Biomedicine. 4(9), 67
  • ZI-YANG CHAN, KAYATRIGOVINDARAJU, PREMANAND KRISHNAN, YUN-YEE LOW, KAM-WENG CHONG, KIEN-THAI YONG, KANG-NEE TING and KUAN-HON LIM, 2019. Phytochemsitry Letters. 30, 93-98
  • YEAP, JOANNE SOON-YEE, LIM, KUAN-HON, YONG, KIEN-THAI, LIM, SIEW-HUAH, KAM, TOH-SEOK and LOW, YUN-YEE, 2019. JOURNAL OF NATURAL PRODUCTS. 82(2), 324-329
  • KRISHNAN, PREMANAND, MAI, CHUN-WAI, YONG, KIEN-THAI, LOW, YUN-YEE and LIM, KUAN-HON, 2019. TETRAHEDRON LETTERS. 60(11), 789-791
  • EZEOKE, M.C., KRISHNAN, P., SIM, D.S.Y., LIM, S.H., LOW, Y.Y., CHONG, K.W. and LIM, K.H., 2018. Phytochemistry. 146, 75-81
  • MEI-KEE LEE, KUAN-HON LIM, PAUL MILLNS, SURESH KUMAR MOHANKUMAR, SZU-TING NG, CHON-SENG TAN, SUE-MIAN THEN and YVONNE MBAKI, 2018. Phytomedicine. 42, 172-179
  • MEI-KEE LEE, PAUL MILLNS, YVONNE MBAKI, SZU-TING NG, CHON-SENG TAN, KUAN-HON LIM, SUE-MIAN THEN, SURESH KUMAR MOHANKUMAR and KANG-NEE TING, 2018. Data in Brief 18. 1322-1326
  • ABUBAKAR, I.B, LIM, K.-H. and T.-S. KAM, 2018. Journal of Biologically Active Products from Nature. 8(1), 21-27
  • SMEDLEY, CHRISTOPHER J., STANLEY, PAUL A., QAZZAZ, MOHANNAD E., PROTA, ANDREA E., OLIERIC, NATACHA, COLLINS, HILARY, EASTMAN, HARRY, BARROW, ANDREW S., LIM, KUAN-HON, KAM, TOH-SEOK, SMITH, BRIAN J., DUIVENVOORDEN, HENDRIKA M., PARKER, BELINDA S., BRADSHAW, TRACEY D., STEINMETZ, MICHEL O. and MOSES, JOHN E., 2018. SCIENTIFIC REPORTS. 8,
  • PREMANAND KRISHNAN, FONG-KAI LEE, KAM-WENG CHONG, CHUN-WAI MAI, AZIRA MUHAMAD, SIEW-HUAH LIM, YUN-YEE LOW, KANG-NEE TING and KUAN-HON LIM, 2018. Organic Letters. 20, 8014-8018
  • SOO, HSIEN-CHUEN, CHUNG, FELICIA FEI-LEI, LIM, KUAN-HON, YAP, VERONICA ALICIA, BRADSHAW, TRACEY D., HII, LING-WEI, TAN, SI-HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, LEONG, CHEE-ONN and MAI, CHUN-WAI, 2017. PLOS ONE. 12(1),
  • CHUNG FF, TAN PF, RAJA VJ, TAN BS, LIM KH, KAM TS, HII LW, TAN SH, SEE SJ, TAN YF, WONG LZ, YAM WK, MAI CW, BRADSHAW TD and LEONG CO, 2017. Scientific reports. 7, 42504
  • ABUBAKAR, IBRAHIM BABANGIDA, LIM, KUAN-HON, KAM, TOH-SEOK and LOH, HWEI-SAN, 2017. PHYTOMEDICINE. 30, 74-84
  • AL-KHDHAIRAWI, AMJAD AYAD QATRAN, KRISHNAN, PREMANAND, MAI, CHUN-WAI, CHUNG, FELICIA FEI-LEI, LEONG, CHEE-ONN, YONG, KIEN-THAI, CHONG, KAM-WENG, LOW, YUN-YEE, KAM, TOH-SEOK and LIM, KUAN-HON, 2017. JOURNAL OF NATURAL PRODUCTS. 80(10), 2734-2740
  • QAZZAZ, M.E., RAJA, V.J., LIM, K.H., KAM, T.S., LEE, J.B., GERSHKOVICH, P. and BRADSHAW, T.D., 2016. Cancer Letters. 370, 185-197
  • YAP, V.A., QAZZAZ, M.E., RAJA, V.J., BRADSHAW, T.D., LOH, H.-S., SIM, K.-S., YONG, K.-T., LOW, Y.-Y. and LIM, K.-H., 2016. Phytochemistry Letters. 15, 136-141
  • ABUBAKAR, I.B., LIM, K.-H., KAM, T.-S. and LOH, H.-S., 2016. Journal of Ethnopharmacology. 184, 107鈥�118
  • WONG, S.P., CHONG, K.W., LIM, K.H., LIM, S.H., LOW, Y.Y. and KAM, T.S., 2016. ORGANIC LETTERS. 18, 1618-1621
  • LEE, M.K., TAN, C.S., NG, S.T., LIM, K.H. and TING, K.N., 2016. Lignosus rhinocerotis on Airway Muscle Relaxation In: 19th ISMS Congress, at Amsterdam, The Netherlands.
  • ABUBAKAR, I.B., LIM, K.-H. and LOH, H.-S., 2015. Natural Product Research. 29(22), 2137-2140
  • YAP, V.A., LOONG, B.-J., TING, K.N., LOH, H.-S., YONG, K.-T., LOW, Y.-Y., KAM, T.-S. and LIM, K.-H., 2015. Phytochemistry. 109, 96-102
  • SANTIAGO, C., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. Molecules. 20(3), 4473-4482
  • SANTIAGO, C., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. BMC Complementary and Alternative Medicine. 15, 79
  • LIM, K.H., RAJA, V.J., BRADSHAW, T.D., LIM, S.H., LOW, Y.Y. and KAM, T.S., 2015. Journal of Natural Products. 78(5), 1129-1138
  • SANTIAGO, C., PANG, E.L., LIM, K.-H., LOH, H.-S. and TING, K.N., 2015. BMC Complementary and Alternative Medicine. 15, 178
  • SUET-PICK WONG, CHEW-YAN GAN, KUAN-HON LIM, KANG-NEE TING, YUN-YEE LOW and TOH-SEOK KAM, 2015. Organic Letters. 17(14), 3628-3631
  • LOONG, B.J., TAN, J.H., LIM, K.H., MBAKI, Y. and TING, K.N., 2015. Naunyn-Schmiedeberg's Archives of Pharmacology. 388(10), 1061-1067
  • LIM, S.H., GAN, C.Y., LOW, Y.Y., LIM, K.H. and KAM, T.S., 2015. Lumutinines A-D, Linearly-fused Macroline-Macroline and Macroline-Sarpagine Bisindoles from Alstonia macrophylla In: 5th International Conference for Young Chemists, at Penang, Malaysia.
  • SANTIAGO, C., PANG, E.L., LIM, K.H., LOH, H.S. and TING, K.N., 2014. BioMed Research International. 965348
  • LOW, Y.Y., HONG, F.J., LIM, K.H., THOMAS, N.F. and KAM, T.S., 2014. Journal of Natural Products. 77(2), 327-338
  • RAJA, V.J., LIM, K.H., LEONG, C.O., KAM, T.S. and BRADSHAW, T.D., 2014. Investigational new drugs. 32(5), 838-50
  • NGE CE, GAN CY, LIM KH, TING KN, LOW YY and KAM TS, 2014. Organic Letters. 16(24), 6330-3
  • TAN, S.J., LIM, K.H., SUBRAMANIAM, G. and KAM, T.S., 2013. Phytochemistry. 85, 194-202
  • LIM, K.H., KOMIYAMA, K., KAM, T.S., LIM, K.H., THOMAS, N.F. and KAM, T.S., 2012. Journal of Natural Products. 75, 945-950
  • WIJAYA, S., TING, K.N., KHOO, T.J., LIM, K.H., LOH, H.S. and WIART, C., 2011. Journal of Complementary and Integrative Medicine. 8(1), 13
  • OTHMAN, M., LOH, H.S., WIART, C., KHOO, T.J., LIM, K.H. and TING, K.N., 2011. Journal of Microbiological Methods. 84(2), 161-166
  • LIM, S.W., TING, K.N., BRADSHAW, T., ZEENATHUL, N.A., WIART, C., KHOO, T.J., LIM, K.H. and LOH, H.S., 2011. Journal of Ethnopharmacology. 138, 616-623
  • LOW, Y.Y., LIM, K.H., CHOO, Y.M., PANG, H.S., ETOH, T., HAYASHI, M., KOMIYAMA, K. and KAM, T.S., 2010. Tetrahedron Letters. 51, 269-272
  • LIM, K.H., THOMAS, N.F., THOMAS, N.F. and KAM, T.S., 2009. Phytochemistry. 70, 424-429
  • LIM, K.H., SIM, K.M. and KAM, T.S., 2009. Phytochemistry. 70, 1182-1186
  • LIM, K.H. and KAM, T.S., 2009. Tetrahedron Letters. 50, 3756-3759
  • LIM, K.H. and KAM, T.S., 2009. Helvetica Chimica Acta. 92, 1895-1902
  • LIM, K.H., ETOH, T., HAYASHI, M., LIM, K.H. and KAM, T.S., 2009. Tetrahedron Letters. 50, 752-754
  • LOW, Y.Y., SUBRAMANIAM, G., LIM, K.H., WONG, R.C.S., ROBINSON, W.T. and KAM, T.S., 2009. Tetrahedron. 65, 6873-6876
  • LIM, K.H., LOW, Y.Y., TAN, G.H., KAM, T.S. and LIM, T.M., 2008. Helvetica Chimica Acta. 91, 1559-1566
  • LIM, KUAN-HON and KAM, TOH-SEOK, 2008. Some novel biologically active alkaloids from Tabernaemontana and Kopsia In: International Conference on Molecular Chemistry, November 2008, Kuala Lumpur.
  • LIM, K.H., HIRAKU, O., KOMIYAMA, K. and KAM, T.S., 2008. Journal of Natural Products. 71, 1591-1594
  • LIM, K.H. and KAM, T.S., 2008. Phytochemistry. 69, 558-561
  • KAM, TOH-SEOK and LIM, KUAN-HON, 2008. Alkaloids of Kopsia. In: CORDELL, G. A., ed., The Alkaloids: Chemistry and Biology 66. Academic Press: The Netherlands. 1-111
  • LIM, K.H., HIRAKU, O., KOMIYAMA, K., KOYANO, T., HAYASHI, M. and KAM, T.S., 2007. Journal of Natural Products. 70, 1302-1307
  • LOW, YUN-YEE, LIM, KUAN-HON and KAM, TOH-SEOK, 2007. Biomimetic oxidative transformations of pericine: Partial synthesis of apparicine and valparicine, a new pentacyclic indole alkaloid from Kopsia In: 12th Asian Chemical Congress, August 2007, Kuala Lumpur.
  • LIM, K.H. and KAM, T.S., 2007. Helvetica Chimica Acta. 90, 31-35
  • LIM, K.H., KOMIYAMA, K. and KAM, T.S., 2007. Tetrahedron Letters. 48, 1143-1145
  • LIM, K.H., LOW, Y.Y. and KAM, T.S., 2006. Tetrahedron Letters. 47, 5037-5039
  • LIM, K.H. and KAM, T.S., 2006. Organic Letters. 8, 1733-1735
  • LIM, KUAN-HON and KAM, TOH-SEOK, 2006. Structure, biological activity, and partial synthesis of some novel Kopsia alkaloids In: 22nd Annual Seminar of the Malaysian Natural Product Society and 5th Asian Network of Research on Antidiabetic Plants International Seminar (Oral Presentation), November 2006, Kuala Lumpur.
  • LIM, K.H. and KAM, T.S., 2006. Tetrahedron Letters. 47, 8653-8655
  • KAM, T.S., SUBRAMANIAM, G., LIM, K.H. and CHOO, Y.M., 2004. Tetrahedron Letters. 45, 5995-5998
  • KAM, T.S., LIM, K.H., YOGANATHAN, K., HAYASHI, M. and KOMIYAMA, K., 2004. Tetrahedron. 60, 10739-10745

School of Pharmacy

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