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School of Medicine
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Caroline Rick

Associate Professor, Faculty of Medicine & Health Sciences

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Biography

Following a degree, PhD and post-doctoral lab-based research, I had a career change and started working in Clinical Trials management in 2005 (to present day). My research is mainly in Clinical Trials in Neurology, Elderly Care, complex Interventions and some work in Test Evaluation Trials. I am also the Nottingham Clinical Trials Unit (NCTU) lead for Patient and Public involvement and Engagement (PPIE) in Clinical Trials

I moved to the 海角黑料 to an Associate Professor in Clinical Trials in 2019.

Expertise Summary

I have been involved in the design, day to day management, analysis and dissemination of trials for over 18 years. I have worked on Trials in a wide range of neurological and non-neurological conditions and am particularly interested in complex intervention trials involving Allied Health Professions. I have also been involved in Test Evaluation Trials and trials of Medical and surgical interventions,

I sit on the UK CRC Task and Finish group for PPIE and the 海角黑料, School of Medicine PPIE group lead PPIE at NCTU.

Research Summary

I am currently working on Clinical Trials including:

1. )

Source: NIHR HTA

Chief Investigator: Prof A. Abhishek

2. Randomised controlled trial of a new relief inhaler in mild asthma (The Relief Trial)

Source NIHR HTA

Chief Investigator: Prof T. Harrison

3. Follow-up and structured monitoring for adults offered a NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial

Source: NIHR HTA

Chief Investigator: Prof K. Munro

4. Prophylactic therapy in Care Homes Trial: PROTECT-CH.

Source: NIHR

Chief Investigator: Prof P. Bath

5. The COACH trial. A randomised controlled trial of cochlear implantation versus hearing aids in adults with severe hearing loss

Source: Cochlear Inc

Chief Investigator: Prof P. Kitterick & Doug Hartley

6. Tranexamic acid for hyper acute spontaneous intracerebral haemorrhage TICH-3

Source: NIHR HTA

Chief Investigator: Prof N. Sprigg

7. In vivo serial neuromelanin MRI to assess depigmentation rates in the substantia nigra of early Parkinson's disease

Source: Weston Brain Institute (From Feb 2020)

Chief Investigator: Prof D Auer

8. Developing an Artificial Intelligence augmented diagnostic imaging strategy for patients with occult scaphoid fractures of the wrist (AI-MRI)

Source: 海角黑料

A. Karantana, various

9. PD MED: A large randomised assessment of the relative cost-effectiveness of different classes of drugs for Parkinson's disease (Extension)

Source: NIHR HTA

Gray R, various

Recent Publications

  • SACKLEY CM, SMITH CH, RICK CE, BRADY MC, IVES N, PATEL S, WOOLLEY R, DOWLING F, PATEL R, ROBERTS H, JOWETT S, WHEATLEY K, KELLY D, SANDS G, CLARKE CE and , 2018. Pilot and feasibility studies. 4, 30
  • HERD CP, TOMLINSON CL, RICK C, SCOTTON WJ, EDWARDS J, IVES N, CLARKE CE and SINCLAIR A, 2018. The Cochrane database of systematic reviews. 6, CD011616
  • OTTRIDGE R, MOLLAN SP, BOTFIELD H, FREW E, IVES NJ, MATTHEWS T, MITCHELL J, RICK C, SINGHAL R, WOOLLEY R and SINCLAIR AJ, 2017. BMJ open. 7(9), e017426
  • MARKEY KA, OTTRIDGE R, MITCHELL JL, RICK C, WOOLLEY R, IVES N, NIGHTINGALE P and SINCLAIR AJ, 2017. JMIR research protocols. 6(9), e181

Past Research

Selected references:

  1. Leighton P, Sprange K, Robinson K, Rick C. . Eur J Public Health. 2022 Oct; 32(Suppl 3): ckac129.751.
  2. Gordon AL, Rick C, Juszczak E, Montgomery A, Howard R, Guthrie B, Lim WS, Shenkin S, Leighton P, Bath PM, the PROTECT-CH triallists. . Age Ageing. 2022
  3. ; ; ; ; ; ; ; ; ; ; ; ; for the PD MED Collaborative Group (2021) Long-term Effectiveness of Adjuvant Treatment With Catechol-O-Methyltransferase or Monoamine Oxidase B Inhibitors Compared With Dopamine Agonists Among Patients With Parkinson Disease Uncontrolled by Levodopa TherapyThe PD MED Randomized Clinical Trial JAMA Neurol.
  4. Scobie S, Jowett S , Lambe T, Patel S, Woolley R, Ives N, Rick C, Smith C, Brady MC, Clarke C and Sackley C. (2021) Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: preliminary cost鈥慶onsequence analysis of the PD COMM pilot randomised controlled trial. Pilot Feasibility Stud (2021) 7:154
  5. Susan P. Mollan, James L. Mitchell, Ryan S. Ottridge, Magda Aguiar, Andreas Yiangou, Zerin Alimajstorovic, David M. Cartwright, Olivia Grech, Gareth G. Lavery, Connar S. J. Westgate, Vivek Vijay, William Scotton, Ben R. Wakerley, Tim D. Matthews, Alec Ansons, Simon J. Hickman, James Benzimra, Caroline Rick, Rishi Singhal, Abd A. Tahrani, Kristian Brock, Emma Frew, Alexandra J. Sinclair. . JAMA Neurol. 2021 Jun; 78(6): 678-686.
  6. , , , , , , , , , , , (2021) Cost-Effectiveness of Dopamine Agonists and Monoamine Oxidase B Inhibitors in Early Parkinson's Disease. Mov Dis
  7. Rick C*, Mallett S*, Brown J, Ottridge R, Palmer A, Parker V, Priest L, and Deeks JJ. (2020) Test evaluation trials present different challenges for trial managers compared to Intervention trials. 21, 987 * joint first author https://doi.org/10.1186/s13063-020-04861-7
  8. Sackley C*; Rick C*; Au P; Brady M; Beaton G; Burton C; Caulfield M; Dickson S; Dowling F; Hughes M; Ives N; Jowett S; Masterson-Algar P; Nicoll A; Patel S; Smith CH; Woolley R; Clarke CE (2020) A Multi-Centre Randomised Controlled Trial to Compare the Clinical and Cost Effectiveness of Lee Silverman Voice Treatment Versus Standard NHS Speech and Language Therapy Versus Control in Parkinson's Disease: a Study Protocol for a Randomised Controlled Trial. 27th May 2020, Trials 21: 436 * joint first author DOI:
  9. Markey, K, Mitchell, J, Botfield, H, Ottridge, RS, Matthews, T, Krishnan, A, Woolley, R, Westgate, C, Yiangou, A, Alimajstorovic, Z, Shah, P, Rick, C, Ives, N, Taylor, AE, Gilligan, LC, Jenkinson, C, Arlt, W, Scotton, W, Fairclough, R, Singhal, R, Stewart, PM, Tomlinson, JW, Lavery, GG, Mollan, SP, Sinclair, AJ. 11尾-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Idiopathic Intracranial Hypertension: A Double-Blind Randomized Controlled Trial. Brain Communications, (2020).
  10. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A: Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine 2019 BMJ Open Vol 9 (7):e027953 DOI:
  11. Smith CH, Patel S, Woolley RL, Brady MC, Rick CE, Halfpenny R, Rontiris A, Knox-Smith L, Dowling F, Clarke CE, Au P, Ives N, Wheatley K, Sackley CM. Clin Linguist Phon. 2019 Apr 29:1-8.
  12. Herd CP, Tomlinson CL, Rick C, Scotton WJ, Edwards J, Ives N, Clarke CE, Sinclair A Botulinumtoxins for the prevention of migraine in adults (Review) Cochrane Database of Systematic Reviews 2018, Issue 6. Art. No: CD011616.
  13. Sackley CM, Smith CH, Rick C, Brady MC, Patel S, Woolley R, Dowling F, Patel R, Roberts R, Jowett S, Wheatley K, Kelly D, Sands G, Clarke CE and on behalf of the PD COMM Pilot Collaborative Group Lee Silverman Voice Treatment versus standard speech and language therapy versus control in Parkinson's disease: a pilot randomised controlled trial (PD COMM pilot). Pilot and Feasibility Studies (2018) 4:30
  14. ; ; ; ; ; ; ; . Assessing the Efficacy and Safety of an 11beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor (AZD4017) in the Idiopathic Intracranial Hypertension Drug Trial, IIH:DT: Clinical Methods and Design for a Phase II Randomized Controlled Trial. JMIR Research Protocols, 2017, 6(9) 181.
  15. ; ; ; ; ; ; ; ; ; ; . Randomised controlled trial of bariatric surgery versus a community weight loss programme for the sustained treatment of idiopathic intracranial hypertension: the Idiopathic Intracranial Hypertension Weight Trial (IIH:WT) protocol. BMJ Open, 2017, 7(9)
  16. ; ; ; ; ; ; ; ; ; . The PD COMM trial: a protocol for the process evaluation of a randomised trial assessing the effectiveness of two types of SLT for people with Parkinson's disease. 2017, Trials, 18
  17. , , , , , , . Coding accuracy for Parkinson's disease hospital admissions: implications for healthcare planning in the UK. , 2017, 147, 4-9
  18. ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; on behalf of the . Refining Ovarian Cancer Test accuracy Scores (ROCkeTS): protocol for a prospective longitudinal test accuracy study to validate new risk scores in women with symptoms of suspected ovarian cancer. BMJ Open 2016, 6 (8).
  19. ; ; ; ; ; ; ; . Patients' experiences of deep brain stimulation for Parkinson's disease: a qualitative systematic review and synthesis. BMJ OPEN (2016) Volume: 6 (6) e011525
  20. McIntosh, Emma; Gray, Alastair; Daniels, Jane; et al. Group Author(s): PD SURG Collaborators Grp MOVEMENT DISORDERS 2016, 31 (8)1173-1182
  21. Clarke CE, Patel S, Ives N, Rick C, Dowling F, Woolley R, Wheatley K, Walker M, Sackley C. Physiotherapy and Occupational therapy versus no therapy in mild to moderate Parkinson's disease. A randomised controlled trial. JAMA Neurology. 2016;73(3):291-299
  22. ; ; ; . A systematic review of interventions to reduce hospitalisation in Parkinson's disease. PARKINSONISM & RELATED DISORDERS 2016, 24, 3-7
  23. Stow R, Ives N, Smith C, Rick C, and Rushton A. A cluster randomised feasibility trial evaluating nutritional interventions in the treatment of malnutrition in care home adult residents. Trials (2015) 16:433 1 - 21
  • SACKLEY CM, SMITH CH, RICK CE, BRADY MC, IVES N, PATEL S, WOOLLEY R, DOWLING F, PATEL R, ROBERTS H, JOWETT S, WHEATLEY K, KELLY D, SANDS G, CLARKE CE and , 2018. Pilot and feasibility studies. 4, 30
  • HERD CP, TOMLINSON CL, RICK C, SCOTTON WJ, EDWARDS J, IVES N, CLARKE CE and SINCLAIR A, 2018. The Cochrane database of systematic reviews. 6, CD011616
  • OTTRIDGE R, MOLLAN SP, BOTFIELD H, FREW E, IVES NJ, MATTHEWS T, MITCHELL J, RICK C, SINGHAL R, WOOLLEY R and SINCLAIR AJ, 2017. BMJ open. 7(9), e017426
  • MARKEY KA, OTTRIDGE R, MITCHELL JL, RICK C, WOOLLEY R, IVES N, NIGHTINGALE P and SINCLAIR AJ, 2017. JMIR research protocols. 6(9), e181
  • MASTERSON-ALGAR P, BURTON CR, BRADY MC, NICOLL A, CLARKE CE, RICK C, HUGHES M, AU P, SMITH CH and SACKLEY CM, 2017. Trials. 18(1), 397
  • MUZERENGI S, RICK C, BEGAJ I, IVES N, EVISON F, WOOLLEY RL and CLARKE CE, 2017. Public health. 146, 4-9
  • CLARKE CE, PATEL S, IVES N, RICK CE, WOOLLEY R, WHEATLEY K, WALKER MF, ZHU S, KANDIYALI R, YAO G and SACKLEY CM, 2016. Health technology assessment (Winchester, England). 20(63), 1-96
  • CLARKE CE, PATEL S, IVES N, RICK CE, DOWLING F, WOOLLEY R, WHEATLEY K, WALKER MF, SACKLEY CM and , 2016. JAMA neurology. 73(3), 291-9
  • MCINTOSH, E., GRAY, A., DANIELS, J., GILL, S., IVES, N., JENKINSON, C., MITCHELL, R., PALL, H., PATEL, S., QUINN, N., RICK, C., WHEATLEY, K. and WILLIAMS, A., 2016. Mov Disord. 31(8), 1173-82
  • SUNDAR S, RICK C, DOWLING F, AU P, SNELL K, RAI N, CHAMPANERIA R, STOBART H, NEAL R, DAVENPORT C, MALLETT S, SUTTON A, KEHOE S, TIMMERMAN D, BOURNE T, VAN CALSTER B, GENTRY-MAHARAJ A, MENON U, DEEKS J and , 2016. BMJ open. 6(8), e010333
  • MATHERS J, RICK C, JENKINSON C, GARSIDE R, PALL H, MITCHELL R, BAYLISS S and JONES LL, 2016. BMJ open. 6(6), e011525
  • MUZERENGI S, HERD C, RICK C and CLARKE CE, 2016. Parkinsonism & related disorders. 24, 3-7
  • STOW R, IVES N, SMITH C, RICK C and RUSHTON A, 2015. Trials. 16, 433
  • JENKINSON C, CLARKE C, GRAY R, HEWITSON P, IVES N, MORLEY D, RICK C, WHEATLEY K and WILLIAMS A, 2015. Parkinsonism & related disorders. 21(11), 1312-6
  • STOW R, RUSHTON A, IVES N, SMITH C and RICK C, 2015. Pilot and feasibility studies. 1, 3
  • , GRAY R, IVES N, RICK C, PATEL S, GRAY A, JENKINSON C, MCINTOSH E, WHEATLEY K, WILLIAMS A and CLARKE CE, 2014. Lancet (London, England). 384(9949), 1196-205
  • XIN Y, CLARKE CE, MUZERENGI S, RICK CE, GRAY A, GRAY R, WHEATLEY K, IVES N and MCINTOSH E, 2014. Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research. 17(7), A809
  • CLARKE CE, PATEL S, IVES N, RICK C, WHEATLEY K and GRAY R, 2011. Movement disorders : official journal of the Movement Disorder Society. 26(7), 1187-93
  • TOMLINSON CL, STOWE R, PATEL S, RICK C, GRAY R and CLARKE CE, 2010. Movement disorders : official journal of the Movement Disorder Society. 25(15), 2649-53
  • WILLIAMS A, GILL S, VARMA T, JENKINSON C, QUINN N, MITCHELL R, SCOTT R, IVES N, RICK C, DANIELS J, PATEL S, WHEATLEY K and , 2010. The Lancet. Neurology. 9(6), 581-91

School of Medicine

海角黑料
Medical School
Nottingham, NG7 2UH

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